The DOE is soliciting applications from interdisciplinary teams to address the Genesis Mission National Science and Technology Challenges. This initiative supports a broader national effort, established through a recent Executive Order, to advance AI-driven innovation for solving complex energy, environmental, and security challenges.

The program aims to accelerate scientific discovery and R&D workflows through the development of advanced AI models and frameworks. Competitive projects will demonstrate how AI enables a clear “AI advantage,” providing capabilities, efficiencies, or insights beyond conventional approaches.

Projects funded under this solicitation are expected to propose an approach or cluster of related approaches that will be pursued in two phases in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy.

Teams are encouraged to leverage DOE resources, including National Laboratories, user facilities, industry partnerships, and academic collaborations. Successful outputs are expected to contribute to and integrate with platforms such as the American Science Cloud.

Managing Unit: VPDoR